PROSTAGLANDIN DERIVATIVE - TAISHO PHARMACEUTICAL CO LTD

Title:

PROSTAGLANDIN DERIVATIVE

Document Type and Number:

Japanese Patent JPH08208599

Kind Code:

A

Abstract:

PURPOSE: To obtain the subject physically stable compound expressed by a specific formula, easy to purify and handle, and having pharmacological action on various kinds of nephrotic diseases and ischemic cardiopathy, etc.

CONSTITUTION: This compound is expressed by formula I, e.g. 3-oxa-9-deoxy-9β- chloro-16,17,18,19,20-pentanol-15-cyclohexyl-13,14-didehydro-PGF2α (1S,2R)-(-)-1,2- diphenyl-2-dihydroxyethylamine salt. It is recommended that the compound of formula I be obtained, for example, by reaction of a compound of formula II with 0.5-2 equivalents of (1R,2S)-2-amino-1,2-diphenylethanol of formula III in an inert solvent (e.g. tetrahydrofuran).

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Inventors:

SATOU FUMIE
KAMEO KAZUYA
TANAMI TOORU
KUWATA TSUYOSHI

Application Number:

JP30697795A

Publication Date:

August 13, 1996

Filing Date:

November 27, 1995

Export Citation:

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Assignee:

TAISHO PHARMACEUTICAL CO LTD
SATO FUMIE

International Classes:

A61K31/5575; A61P9/00; A61P9/08; A61K31/557; A61P9/10; A61P13/02; A61P15/00; C07C405/00; (IPC1-7): C07C405/00; A61K31/557

Attorney, Agent or Firm:

Kitagawa Fuzo

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