Title:
プロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JP2012527435
Kind Code:
A
Abstract:
A compound of formula (I) wherein R1 to R15, P1, P2, A, B and Q are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as matriptase inhibitors and are useful in the treatment of matriptase dependent conditions, particularly cancer.
Inventors:
Goswami, Rajib
Buppara, Anil Kumar
Belldandy, Ramesh
Cistra, lameche
Gajiyalam, Chakshsumachi
Ramachandra, Mullaridhara
Buppara, Anil Kumar
Belldandy, Ramesh
Cistra, lameche
Gajiyalam, Chakshsumachi
Ramachandra, Mullaridhara
Application Number:
JP2012511313A
Publication Date:
November 08, 2012
Filing Date:
May 18, 2010
Export Citation:
Assignee:
Orion Corporation
International Classes:
C07C235/54; A61K31/166; A61K31/18; A61K31/192; A61K31/216; A61K31/27; A61K31/4184; A61K31/44; A61K31/445; A61K31/4545; A61K31/455; A61K31/47; A61K31/4709; A61K31/472; A61K31/495; A61K31/496; A61P35/00; A61P35/04; A61P43/00; C07C257/18; C07C259/18; C07C271/16; C07C311/21; C07D211/16; C07D211/26; C07D211/34; C07D211/58; C07D211/62; C07D213/61; C07D213/73; C07D213/75; C07D213/76; C07D213/81; C07D213/82; C07D215/08; C07D217/06; C07D235/30; C07D295/18; C07D295/20; C07D401/06; C07D401/12
Domestic Patent References:
| JP2000515846A | 2000-11-28 |
Foreign References:
| US5691364A | 1997-11-25 | |||
| WO2009027450A1 | 2009-03-05 |
Other References:
JPN7014000985; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４２， Ｎｏ．１０, 1999, １７４９-１７５６
JPN7014000986; Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４０, 2005, ｐｐ．７０１-７２７
JPN7014000987; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．９, 2001, ｐｐ．２８３-２８９
JPN7014000988; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ［Ｏｎｌｉｎｅ］： Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｓｅｒｖｉｃｅ， Ｃｏｌｕｍｂｕｓ， Ｏｈｉｏ， ＵＳＡ． Ｒｅｔｒｉｅｖｅｄ ｆｒｏｍ ＳＴＮ , Ｒｅｇｉｓｔｒｙ Ｎｏ． ９５１９０７-５０-９， ９５１９１７-３８-７
JPN7014000986; Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４０, 2005, ｐｐ．７０１-７２７
JPN7014000987; Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．９, 2001, ｐｐ．２８３-２８９
JPN7014000988; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ［Ｏｎｌｉｎｅ］： Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｓｅｒｖｉｃｅ， Ｃｏｌｕｍｂｕｓ， Ｏｈｉｏ， ＵＳＡ． Ｒｅｔｒｉｅｖｅｄ ｆｒｏｍ ＳＴＮ , Ｒｅｇｉｓｔｒｙ Ｎｏ． ９５１９０７-５０-９， ９５１９１７-３８-７
Attorney, Agent or Firm:
Kawamura Taku
Yousuke Fujimori
Keiko Kato
Masahiro Mishima
Yousuke Fujimori
Keiko Kato
Masahiro Mishima