Title:
PROTEASE-RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 IN REPAIR OF TISSUE DAMAGE
Document Type and Number:
Japanese Patent JP2015057058
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide peptides that promote tissue repair when delivered to the damaged tissue.SOLUTION: The invention provides stromal cell derived factor-1 (SDF-1) peptides which are mutated to be resistant to digestion by the proteases dipeptidyl peptidase IV and matrix metalloproteinase 2 but are maintaining the ability of native SDF-1 to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides, and then implanted at sites of tissue damage to help promotion of repair.
Inventors:
LEE RICHARD
VINCENT SEGERS
VINCENT SEGERS
Application Number:
JP2014205586A
Publication Date:
March 26, 2015
Filing Date:
October 06, 2014
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL
International Classes:
C12N15/09; A61K38/00; A61K47/42; A61K47/48; A61P3/10; A61P9/00; A61P9/10; A61P17/02; A61P25/08; C07K7/08; C07K14/52; C07K19/00
Domestic Patent References:
| JPH07501217A | 1995-02-09 |
Foreign References:
| WO2006073889A2 | 2006-07-13 | |||
| WO2006047315A2 | 2006-05-04 |
Other References:
JPN6013019822; Ｃａｒｄｉｏｖａｓｃ Ｒｅｓ． ２０００ Ｍａｙ；４６（２）：３０７-１５．
JPN6013019825; Ａｍ Ｊ Ｐｈｙｓｉｏｌ Ｈｅａｒｔ Ｃｉｒｃ Ｐｈｙｓｉｏｌ． ２００４ Ｄｅｃ；２８７（６）：Ｈ２８６１-７０．
JPN6013019828; Ｊ Ｂｉｏｌ Ｃｈｅｍ． ２００１ Ａｕｇ １０；２７６（３２）：２９８３９-４５．
JPN6013019830; Ｂｌｏｏｄ． ２００４ Ａｐｒ １；１０３（７）：２４５２-９．
JPN6013019832; Ｊ Ｂｉｏｌ Ｃｈｅｍ． ２００２ Ｍａｙ ３；２７７（１８）：１５６７７-８９．
JPN6013019815; Ｊ Ｂｉｏｌ Ｃｈｅｍ． ２００１ Ｎｏｖ ２３；２７６（４７）：４３５０３-８．
JPN6013019817; Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ Ｕ Ｓ Ａ． １９９８ Ｍａｙ ２６；９５（１１）：６３３１-６．
JPN6013019820; Ｂｌｏｏｄ． ２００４ Ａｐｒ １；１０３（７）：２４５２-９．
JPN6013019825; Ａｍ Ｊ Ｐｈｙｓｉｏｌ Ｈｅａｒｔ Ｃｉｒｃ Ｐｈｙｓｉｏｌ． ２００４ Ｄｅｃ；２８７（６）：Ｈ２８６１-７０．
JPN6013019828; Ｊ Ｂｉｏｌ Ｃｈｅｍ． ２００１ Ａｕｇ １０；２７６（３２）：２９８３９-４５．
JPN6013019830; Ｂｌｏｏｄ． ２００４ Ａｐｒ １；１０３（７）：２４５２-９．
JPN6013019832; Ｊ Ｂｉｏｌ Ｃｈｅｍ． ２００２ Ｍａｙ ３；２７７（１８）：１５６７７-８９．
JPN6013019815; Ｊ Ｂｉｏｌ Ｃｈｅｍ． ２００１ Ｎｏｖ ２３；２７６（４７）：４３５０３-８．
JPN6013019817; Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ Ｕ Ｓ Ａ． １９９８ Ｍａｙ ２６；９５（１１）：６３３１-６．
JPN6013019820; Ｂｌｏｏｄ． ２００４ Ａｐｒ １；１０３（７）：２４５２-９．
Attorney, Agent or Firm:
Spring water Original aim
Masao Haruna
Hirotaka Yamaguchi
Shun Osakabe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shin-ichi Watanabe
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Osakabe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shin-ichi Watanabe
Masato Ozeki
Kazuya Kawamoto