Title:
間葉幹細胞でのタンパク質量産方法
Document Type and Number:
Japanese Patent JP6609034
Kind Code:
B2
Abstract:
The present invention relates to the method for mass production of mesenchymal stem cell-derived proteins including various growth factors and cytokines, a mesenchymal stem cell conditioned medium containing a large amount of protein and produced by the above production method, cosmetic composition and pharmaceutical composition including the above conditioned medium for skin regeneration, anti-wrinkle, alopecia treatment, prevention of hair loss and promotion of hair growth. The method for mass production of the mesenchymal stem cell-derived protein of the present invention can greatly increase the amount of various growth factors and proteins which are known to be not expressed from mesenchymal stem cells or expressed only in very small amounts by the existing culture method, and the mesenchymal stem cell conditioned medium prepared by the above method contains a large amount of various kinds of cytokines and growth factors so that it has the excellent effect on skin regeneration, wrinkle improvement, prevention of hair loss, alopecia treatment and hair growth promotion.
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Inventors:
Jean Hoi
Application Number:
JP2018503447A
Publication Date:
November 20, 2019
Filing Date:
April 01, 2016
Export Citation:
Assignee:
Stem Medicare Company Limited
International Classes:
A61K8/98; C07K14/435; A61K35/28; A61K35/50; A61K38/17; A61P17/00; A61P17/14; A61Q7/00; A61Q19/00
Other References:
Sarah Tzu-Feng Hsiao, et al.,STEM CELLS AND DEVELOPMENT,2012年,Vol.21, No.12,p.2189-2203
REVIVE ORGANTECH, Inc Specification Sheet [online],2015年 3月31日,インターネット
Seung Ho Lee, et al.,ANNALS of DERMATOLOGY,2012年,Vol.24, No.2,p.136-143
The hair growth-promoting effects of adipose tissue-derived stem cells.,Journal of Investigative Dermatology,2009年,Vol.129, SUPPL.1,p.S99,591
REVIVE ORGANTECH, Inc Specification Sheet [online],2015年 3月31日,インターネット
Seung Ho Lee, et al.,ANNALS of DERMATOLOGY,2012年,Vol.24, No.2,p.136-143
The hair growth-promoting effects of adipose tissue-derived stem cells.,Journal of Investigative Dermatology,2009年,Vol.129, SUPPL.1,p.S99,591
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe