酵素ニコチンアミドホスホリボシルトランスフェラーゼの阻害剤としてのピリジニル誘導体

Japanese Patent JP5717730

B2

The present application discloses a compound of the formula (I) wherein Q is optionally substituted pyridyl; p is 0-6. Y is formulae (i), (ii) and (iii) where X is ═O, ═S and ═N—CN, r is 1-12, R is —Z-A, Z is a single bond, —S(═O)2—, >P═O, >C═O, —C(═O)NH—, and —C(═S)NH—; and A is hydrogen, C1-12-alkyl, C3-12-cycloalkyl, —[CH2CH2O]1-10—(C1-6-alkyl), C1-12-alkenyl, aryl, heterocyclyl, and heteroaryl; B is a single bond, —NRN—, —S(═O)2— and —O—; wherein RN is selected from hydrogen, C1-12-alkyl, C3-12-cycloalkyl, —[CH2CH2O]1-10—(C1-6-alkyl), C1-12-alkenyl, aryl, heterocyclyl, and heteroaryl; s is 0-6; and Cy is aryl, cycloalkyl, heterocyclyl, and heteroaryl. The compounds are useful for use as a medicament for the treatment of a disease or a condition caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPRT).

WO/1997/024118	SUBSTITUTED N-[(AMINOIMINOMETHYL OR AMINOMETHYL)PHENYL]PROPYL AMIDES
JP2012051937	NEW ALKYNYL DERIVATIVE AS MODULATOR OF METABOTROPIC GLUTAMIC ACID RECEPTOR
WO/2006/091796	COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING RETINAL DISEASES

Mette Knack Christensen
Fredrik Bierkling

JP2012514466A

May 13, 2015

June 09, 2010

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TopoTarget A/S

C07D213/56; A61K31/4406; A61K31/4433; A61K31/5355; A61K31/5377; A61P1/04; A61P3/10; A61P9/00; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P19/02; A61P19/10; A61P25/00; A61P25/28; A61P29/00; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07D405/12; C07D413/12

JP59193871A
JP2009512726A
JP2212459A
JP2007523073A
JP2002508357A
JP2002537380A

WO2009034258A1
US5696140
EP1674457A1
WO1998054142A1
WO2008025857A1

Chinese Chemical Letters,2009年 3月,Vol.20, No.3,pp.296-299

Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai

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