Title:
PYRROLIDINE DERIVATIVE
Document Type and Number:
Japanese Patent JP3637974
Kind Code:
B2
Abstract:
PURPOSE: To provide a new pyrrolidine derivative having high affinity to the receptor of dopamine I and useful as an agent for treating and preventing hypertension and cardiac failures.
CONSTITUTION: A compound of formula I [Y is -NH-, -(CH2)n- (n is 0-2), -S(O)p- (p is 0-2); R1, R2 are H, OH, -SO2NR3R4 (R3, R4 are H, lower alkyl and acyl, and R3, R4 may be combined to each other together with the bonded N atom to form a ring), -NR5R6 (R5, R6 are H, alkylsulfonyl, acyl, but a case where both R5, R6 are H is excluded, and R5, R6 may form a ring together with the bonded N atom); but a case where both R1, R2 are H or OH, and a case where either of R1, R2 is H and the other is OH are excluded] or its pharmacologically acceptable salt, e.g. (-)-trans-3-(3-aminosulfonyl-2,6-dihydroxyphenyl)methyl-4-(3,4- dihydroxyphenyl)pyrrolidine hydrochloride.
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Inventors:
Hoshino Shihan
Keizo Sato
Shinji Suda
Hitoshi Ikunuma
Naoki Yoneda
Kazutoshi Miyake
Norio Minami
Toshiyuki Matsuoka
Hiroki Ishihara
Nobuyuki Mori
Mitsumasa Shino
Shigeru Sawada
Keizo Sato
Shinji Suda
Hitoshi Ikunuma
Naoki Yoneda
Kazutoshi Miyake
Norio Minami
Toshiyuki Matsuoka
Hiroki Ishihara
Nobuyuki Mori
Mitsumasa Shino
Shigeru Sawada
Application Number:
JP7020794A
Publication Date:
April 13, 2005
Filing Date:
March 16, 1994
Export Citation:
Assignee:
EISAI CO.,LTD.
International Classes:
A61K31/40; A61P9/00; A61P9/04; A61P9/12; A61P43/00; C07D207/08; C07D207/12; C07D207/14; (IPC1-7): C07D207/12; A61K31/40; A61P9/04; A61P9/12; A61P43/00; C07D207/14
Domestic Patent References:
| JP2928307B2 | ||||
| JP2928288B2 |
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