Title:
QUICK RNA MODIFICATION METHOD USING FUNCTIONAL GROUP TRANSITION NUCLEIC ACID
Document Type and Number:
Japanese Patent JP2012056895
Kind Code:
A
Abstract:
To provide a novel compound to quickly modify RNA in a specific sequence and in a specific site.
The compound is shown by general formula II. In the formula, R1 is H, C1-6 alkyl or C1-6 aryl; and X is Br, Cl or I. The compound shown by the formula, and an oligonucleotide containing 6-thio guanosine are made to react to produce a functional group transition nucleic acid, the obtained functional group transition nucleic acid and RNA are made to react to produce RNA into which a functional molecule has been introduced.
Inventors:
SASAKI SHIGEKI
ONIZUKA KAZUMITSU
TANIGUCHI YOSUKE
ONIZUKA KAZUMITSU
TANIGUCHI YOSUKE
Application Number:
JP2010202349A
Publication Date:
March 22, 2012
Filing Date:
September 09, 2010
Export Citation:
Assignee:
UNIV KYUSHU
International Classes:
C07H21/02; C07C49/80; C07C247/04; C07D495/04; C12N15/00
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hisako Nozaki
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hisako Nozaki
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