イメージング及び放射線療法のための放射標識された蛍光性ＰＡＲＰ阻害剤 - The Trustees of the University of Pennsylvania

Title:

イメージング及び放射線療法のための放射標識された蛍光性ＰＡＲＰ阻害剤

Document Type and Number:

Japanese Patent JP7264489

Kind Code:

B2

Abstract:

The present disclosure relates to compounds of Formula I and II, wherein R1-R20 and FL are defined herein. Also provided are methods of targeting alpha-radiation to poly(ADP-ribose)polymerase 1 (PARP-1) enzyme expression, reducing proliferation of cancer cells, reducing proliferation of cancer cells, detecting intact and enzymatically active poly(ADP-ribose)polymerase 1 (PARP-1) enzyme expression, detecting PARP-1 enzyme expression in a subjects tissue sample, monitoring cancer treatment in a subject, or detecting a PARP-1 receptive cancer in a subject.

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Inventors:

March, Robert, H.
Riley, Sean
McVandy, Meheran
Shay, Quiuin
Prima, Daniel, A.
Greenberg, Roger, A.

Application Number:

JP2019565284A

Publication Date:

April 25, 2023

Filing Date:

May 24, 2018

Export Citation:

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Assignee:

The Trustees of the University of Pennsylvania

International Classes:

C07D487/06; A61K31/551; A61K31/69; A61K50/00; A61K51/04; A61P1/04; A61P1/16; A61P1/18; A61P5/00; A61P7/00; A61P11/00; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P19/08; A61P21/00; A61P25/00; A61P35/00; A61P35/02; C07F5/02; C09B57/00; C12Q1/48

Domestic Patent References:

JP2003510328A
JP2012521973A

Foreign References:

WO2016033293A1
WO2012074840A2

Other References:

THE JOURNAL OF NUCLEAR MEDICINE,VOL.58, NO.7,2017年05月04日,1025-1530
Cancer Research,2016年,76(15),4516-4524
MEHRAN MAKVANDI,ABSTRACT B31: POLY(ADP-RIBOSE) POLYMERASE 1 AS A NOVEL TARGET FOR ALPHA-PARTICLE 以下備考,MOLECULAR CANCER RESEARCH,2017年04月,PAGE(S):1-4,https://mcr.aacrjournals.org/content/15/4_Supplement/B31,THERAPY IN HIGH-RISK NEUROBLASTOMA
Radiochimica Acta,1989年,47,137-142
ACTA NATURAE,2016年,VOL.8 No.4(31),33-46
British Journal of Pharmacology,2010年,159,772-786
Org. Lett.,2018年03月21日,20,1752-1755

Attorney, Agent or Firm:

Taro Yaguchi

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