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Title:
REAGENT FOR AMPLIFYING AMYLOID FIBROSIS OF AMYLOID BETA PROTEIN
Document Type and Number:
Japanese Patent JP3910569
Kind Code:
B2
Abstract:

PROBLEM TO BE SOLVED: To provide a method for searching a natural peptide forming amyloid fiber by a template reaction with a small amount of the nucleus of a fibrillated amyloid β-protein to form amyloid fiber and amplifying the fiber to increase its volume, and designing and developing a new artificial peptide usable as a substitute for the natural peptide, a method for the amplification of amyloid fibrosis of the amyloid β-protein, a reagent for the amplification reaction, a method for detecting diseases caused by amyloidosis and a reagent for the detection method.
SOLUTION: The amplification of amyloid fibrosis of amyloid β-protein is carried out by using a reagent containing a peptide composed of the 14th residue to the 23rd residue of amyloid β-peptide or a peptide obtained by substituting all positive-charge side chain amino acids of the above peptide with Lys and all negative-charge side chain amino acids with Glu. The invention further provides a reagent for the amplification method, a method for the detection of diseases caused by amyloidosis using the reagent containing the peptide, a reagent for the detection method and a new artificial peptide usable in the above reagents.


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Inventors:
Kiwa Mihara
Tsuyoshi Takahashi
Hideo Oshima
Application Number:
JP2003295153A
Publication Date:
April 25, 2007
Filing Date:
August 19, 2003
Export Citation:
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Assignee:
Japan Science and Technology Agency
International Classes:
C07K7/06; G01N33/48; C07K4/12; C07K14/47; G01N33/68; (IPC1-7): C07K7/06; G01N33/48; G01N33/68
Foreign References:
WO2003014329A2
Other References:
Biochemistry,2001年,Vol.40,pp.8237-8245
J. Biol. Chem.,1997年,Vol.272, No.19,pp.12601-12605
Proc. Natl. Acad. Sci. USA,2002年,Vol.99, No.22,pp.14126-14131
Attorney, Agent or Firm:
Norio Saeki



 
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