REPLICATION DEFICIENT ADENOVIRAL TNF VECTOR

Japanese Patent JP2012139220

A

To provide replication deficient TNF adenoviral vectors that have greater flexibility in their construction and use, and can provide greater success in the treatment of a tumor or cancer.

There is provided an adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region 12 of the adenoviral genome, (b) a nucleic acid sequence 15 encoding TNF, and (c) a radiation inducible promoter 14 operably linked to the nucleic acid sequence 15 encoding TNF. The invention also provides an adenoviral vector comprising a spacer element 18 of at least 15 base pairs in the E4 region 12 of the adenoviral genome. A method for producing the adenoviral vector and a method for treating a tumor or cancer in a host comprising administering an anti-cancer or anti-tumor effective amount of the adenoviral vector are also provided.

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BROUGH DOUGLAS E
KING C RICHTER
KOVESDI IMRE

JP2012022529A

July 26, 2012

February 03, 2012

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GENVEC INC

C12N15/09; A61K31/7088; A61K31/713; A61K35/12; A61K35/76; A61K38/00; A61K38/19; A61K41/00; A61K48/00; A61P9/10; A61P11/00; A61P11/06; A61P35/00; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/01; C12N7/04; C12N15/28; C12N15/861

JPH11513390A	1999-11-16
JPH11502421A	1999-03-02
JPH11501219A	1999-02-02

Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma

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