RETINOID ACTION CONTROLLER

Japanese Patent JPH10338658

A

To obtain the subject novel compound that has the retinoid physiological activity-enhancing and -inhibiting action and is useful as a medicine, for example, a retinoid action controller.

This compound is represented by the formula [R1 is H, a 1-6C alkyl; R2-R4 are each H, a 1-6C alkyl, alkoxy; X is a difunctional group represented by -C(R5)(R6)- or -NR7- (where R5 is H, OH; R6 is (substituted) phenyl, (substituted) 5- 6-membered nitrogen-containing heterocycle; R7 is H, a 3-12C cycloalkyl)], typically 4-[(5,6,7,8-tetrahydro-5,5,8,8- tetramethylnaphthalen-2-yl) phenylmethyl]benzoic acid. The compound of the formula is used as an active ingredient to prepare the objective controlling agent. The daily dose is 0.01-1,000 mg/adult in the case of oral administration.

KAGECHIKA HIROYUKI
SUGIOKA TATSUO
SAOTOME TOMOMI
NAKAYAMA YUKI
DOI KAZUYUKI

JP4149098A

December 22, 1998

February 24, 1998

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HOECHST MARION ROUSSEL KK
KAGECHIKA HIROYUKI

A61K31/07; A61K31/19; A61K31/195; A61K31/235; A61K31/245; A61K31/40; A61K31/41; A61K31/415; A61K31/445; A61K31/495; A61K31/535; A61K31/5375; A61P3/02; A61P43/00; C07C63/49; C07C65/01; C07C65/17; C07C65/21; C07C65/24; C07C65/26; C07C69/76; C07C69/92; C07C69/94; C07C229/54; C07C229/60; C07D233/56; C07D233/60; C07D249/08; C07D257/04; C07D295/08; C07D295/14; C07D295/155; (IPC1-7): C07C63/49; A61K31/07; A61K31/19; A61K31/195; A61K31/235; A61K31/245; A61K31/40; A61K31/41; A61K31/415; A61K31/445; A61K31/495; A61K31/535; C07C65/01; C07C65/17; C07C65/21; C07C65/24; C07C65/26; C07C69/76; C07C69/92; C07C69/94; C07C229/60; C07D233/60; C07D249/08; C07D257/04; C07D295/08; C07D295/14

Masazumi Imamura (2 outside)

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