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Title:
RXR HOMODIMER FORMATION, BRIDGED BICYCLIC AROMATIC COMPOUND AND USE THEREOF IN CONTROLLED GENE EXPRESSION
Document Type and Number:
Japanese Patent JP2004159664
Kind Code:
A
Abstract:

To provide a method of screening a substance for an ability to effect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing the retinoid X receptor and determining the presence of homodimer formation.

The method of screening a substance for an ability to affect the formation of the retinoid X receptor homodimer, comprises processes for combining the substance and the solution containing the retinoid X receptor, determining the presence of homodimer formation and determining the presence of the homodimer by detecting activation of transcription through the retinoid X receptor homodimer.


Inventors:
PHAHL MAGNUS
ZHANG XIAO-KUN
LEHMANN JURGEN M
DAWSON MARCIA I
CAMERON JAMES F
HOBBS PETER D
JONG LING
Application Number:
JP2004002452A
Publication Date:
June 10, 2004
Filing Date:
January 07, 2004
Export Citation:
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Assignee:
JOLLA CANCER RES FOUND
STANFORD RES INST INT
International Classes:
G01N33/50; A61K31/19; A61K31/335; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/385; A61K31/39; A61P3/00; A61P3/02; A61P5/12; A61P17/00; A61P31/12; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C07C63/49; C07C63/66; C07C65/36; C07C69/738; C07C69/76; C07C233/64; C07D311/58; C07D317/30; C07D319/06; C07D327/04; C07D333/22; C07D333/38; C07D339/06; C07D339/08; C07D409/04; C07K14/705; C12N15/09; G01N33/15; G01N33/53; G01N33/566; G01N33/68; G01N33/74; (IPC1-7): C12N15/09; C07K14/705; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita