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Title:
SOFT GELATIN CAPSULE
Document Type and Number:
Japanese Patent JPH11100326
Kind Code:
A
Abstract:

To obtain a cyclosporin composition not only stable pharmaceutically, but also having high bioavailability from a pharmacokinetic point of view compared to existing products, and enabling the individual difference in its blood level to be reduced.

This cyclosporin-contg. soft capsule is such one that (l) cyclosporin as active ingredient, (2) a cosurfactant, i.e., polyethylene glycol as hydrophilic component or propylene carbonate as non-hydrophilic component or a mixture thereof, (3) an oil component, i.e., a mixture of an ester of fatty acid and monohydric alkanol, medium fatty acid triglyceride and fatty acid monoglyceride, and (4) a compound with an HLB number of 8-17 as surfactant, are included in a gelatin film containing both polyethylene glycol and propylene glycol as plasticizer.


Inventors:
WOO JONG SOO (KR)
WOO JONG SOO
Application Number:
JP19473998A
Publication Date:
April 13, 1999
Filing Date:
July 09, 1998
Export Citation:
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Assignee:
NOVARTIS AG
International Classes:
A61K9/107; A61K9/48; A61K38/00; A61J3/07; A61K38/13; A61K47/08; A61K47/14; A61P29/00; A61P37/00; A61P37/06; C07K7/64; (IPC1-7): A61K38/00; A61J3/07; A61K9/48
Attorney, Agent or Firm:
Etsushi Kotani (1 person outside)