Title:
SOLID FORMS OF TOLL-LIKE RECEPTOR MODULATOR
Document Type and Number:
Japanese Patent JP2019056017
Kind Code:
A
Abstract:
To provide solid forms of a toll-like receptor modulator.SOLUTION: The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making. The present disclosure relates generally to crystalline solid forms of an antiviral pharmaceutical compound 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, methods of making the forms, and their therapeutic methods of use.SELECTED DRAWING: Figure 1
Inventors:
PATRICIA ANDRES
BRANDON HEATH BROWN
KRISTA MARIE DIAZ
KIM YOO JOONG
PAUL ROETHLE
WANG FANG
VALERIYA SMOLENSKAYA
BRANDON HEATH BROWN
KRISTA MARIE DIAZ
KIM YOO JOONG
PAUL ROETHLE
WANG FANG
VALERIYA SMOLENSKAYA
Application Number:
JP2019007572A
Publication Date:
April 11, 2019
Filing Date:
January 21, 2019
Export Citation:
Assignee:
GILEAD SCIENCES INC
International Classes:
C07D487/04; A61K31/519; A61K45/00; A61P31/12; A61P31/20; A61P43/00
Domestic Patent References:
| JP2014505045A | 2014-02-27 |
Other References:
ROETHLE, P. A. ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, JPN6018004689, 2013, pages 7324 - 7333, ISSN: 0004583761
芦澤 一英、他, 医薬品の多形現象と晶析の科学, JPN7015003233, 20 September 2002 (2002-09-20), pages 305 - 317, ISSN: 0004583762
松岡 正邦, 結晶多形の基礎と応用, vol. 普及版 第１刷, JPN7017001304, 22 October 2010 (2010-10-22), pages 105 - 117, ISSN: 0004583763
芦澤 一英、他, 医薬品の多形現象と晶析の科学, JPN7015003233, 20 September 2002 (2002-09-20), pages 305 - 317, ISSN: 0004583762
松岡 正邦, 結晶多形の基礎と応用, vol. 普及版 第１刷, JPN7017001304, 22 October 2010 (2010-10-22), pages 105 - 117, ISSN: 0004583763
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita