Title:
SPRAY-DRIED DISPERSIONS AND FORMULATIONS OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)-1-(1,1,1-TRIFLUORO PROPAN-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE
Document Type and Number:
Japanese Patent JP2023116503
Kind Code:
A
Abstract:
To provide improved formulations for BTK inhibitors, particularly for BTK inhibitors that exhibit low solubility.SOLUTION: The present invention provides a crystalline form which is (S)-5-amino-3-(4-((5-fluoro-2- methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamid, having an X-ray powder diffraction pattern comprising peaks at 2θ values of 15.8±0.2, 16.2±0.2, and 11.9±0.2°.SELECTED DRAWING: None
Inventors:
BARBARA J BRANDHUBER
LAUREN T BRENT
CHARLES TODD EARY
ANDREW KENNA
FIRAS KHAN
VIVIAN F H RENSHAW
STACEY RENEE SPENCER
NICOLAS GUISOT
LAUREN T BRENT
CHARLES TODD EARY
ANDREW KENNA
FIRAS KHAN
VIVIAN F H RENSHAW
STACEY RENEE SPENCER
NICOLAS GUISOT
Application Number:
JP2023085024A
Publication Date:
August 22, 2023
Filing Date:
May 24, 2023
Export Citation:
Assignee:
LOXO ONCOLOGY INC
International Classes:
C07D231/38; A61K31/415; A61K45/00; A61P1/04; A61P17/00; A61P17/04; A61P19/02; A61P19/10; A61P21/04; A61P25/00; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Norio Omori
Previous Patent: 運転者の自動特定
Next Patent: Cathode Current Collector Structure of Molten Carbonate Fuel Cell
Next Patent: Cathode Current Collector Structure of Molten Carbonate Fuel Cell