Title:
STABLE CRYSTALLINE (6S)-AND (6R)-TETRAHYDROFOLIC ACID
Document Type and Number:
Japanese Patent JP3419585
Kind Code:
B2
Abstract:
PURPOSE: To provide the subject compound having high chemically and optically purity and excellent stability.
CONSTITUTION: Crystalline (6S)-tetrahydrofolic acid and crystalline (6R)- tetrahydrofolic acid. The crystalline (6S)-tetrahydrofolic acid is obtained, for example, by crystallizing (6R)- or (6R,S)-tetrahydrofolic acid in a polar medium (preferably water and a mixture of water with a water solubility-inducing polar solvent) at a pH of ≥3.5, preferably 3.5-6.5. The crystalline (6R)-tetrahydrofolic acid is obtained, for example, by crystallizing (6R)- or (6R,S)-tetrahydrofolic acid in the above-described medium at a pH of ≥2, preferably 2-5.5. The pH value is preferably constantly maintained during the crystallization.
Inventors:
Hans Rudolf Miular
Martin Ullman
Rudolph Moser
Tomas Amman
Martin Ullman
Rudolph Moser
Tomas Amman
Application Number:
JP10888195A
Publication Date:
June 23, 2003
Filing Date:
May 02, 1995
Export Citation:
Assignee:
Eproba Actien Gezershyaft
International Classes:
A61K31/505; A61K31/519; A61K31/525; A61P3/02; A61P7/06; A61P17/06; A61P19/02; A61P29/00; A61P33/10; A61P37/06; A61P39/02; A61P43/00; C07D475/04; C07D239/00; C07D241/00; (IPC1-7): C07D475/04; A61K31/519; A61P7/06; A61P39/02
Domestic Patent References:
| JP6211857A | ||||
| JP491089A | ||||
| JP4733127B1 |
Attorney, Agent or Firm:
Mitsufumi Esaki (2 others)
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