STEREOSPECIFIC PRODUCTION OF HEXAHYDRODIBENZOPYRANONES AND INTERMEDIATE THEREOF

Title:

STEREOSPECIFIC PRODUCTION OF HEXAHYDRODIBENZOPYRANONES AND INTERMEDIATE THEREOF

Document Type and Number:

Japanese Patent JPS5359670

Kind Code:

A

Abstract:

An optically active 4-(4-substituted-2,6-dihydroxyphenyl)-6,6-dimethyl-2-norpinanone is reacted with a protonic acid to provide an optical isomer of a cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H- dibenzo[b,d]pyran-9-one. Reaction of said norpinanone with a Lewis acid provides an optical isomer of trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9 H-dibenzo[b,d]pyran-9-one. The optically active norpinanones are prepared by reaction of a 5-substituted-resorcinol with an optically active 6,6-dimethyl-2,4-diacetoxy-2-norpinene or an optically active 6,6-dimethyl-2,2-diacetoxy-3-norpinene, which compounds are derived from optically active beta -pinenes.

More Like This:

WO/2017/045053	CANNABINOID-CONTAINING ORAL PHARMACEUTICAL COMPOSITION, METHOD FOR PREPARING AND USING SAME
WO/1998/016239	CITRUS PEEL EXTRACT AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR
JP2008088119	ANTI-NEOVASCULAR COMPOSITION COMPRISING MARINE ORGANISM PHOSPHOLIPID AND GENISTEIN

Inventors:

ROBAATO EI AASHIYAA
UIRIAMU EI DEI

Application Number:

JP8148977A

Publication Date:

May 29, 1978

Filing Date:

July 04, 1977

Export Citation:

Click for automatic bibliography generation Help

Assignee:

LILLY CO ELI

International Classes:

A61K31/352; C07C69/12; C07C45/00; C07C49/747; C07C67/00; C07C69/14; C07C69/16; C07D311/80; (IPC1-7): C07D311/80

Previous Patent: JPS5359669

Next Patent: 膜厚測定装置および膜厚測定方法