Title:
STERILIZATION FOR IMMNOGLOBLIN SOLUTION
Document Type and Number:
Japanese Patent JPS6485929
Kind Code:
A
Abstract:
PURPOSE: To pasteurize a dilute aqueous solution of immunoglobulin holding its physiological activity with only minimum association by heating the solution under low ion strength and weakly acidic conditions. CONSTITUTION: An aqueous solution of immunoglobulin of <=5wt.%, preferably <=2wt.% is heated under an ion strength (ion strength is lower than that of 0.05 mM aqueous saline solution) and a pH of 3.5-6.5, preferably 4-6 at 35-75 deg.C, preferably 50-60 deg.C to inactivate viruses which exist in an association of <=5%, a the physiological activity of the immunoglobulin is sustained. The immunoglobulin is, for example, gamma globulin, venous immunoglobulin, hyperimmunoglobulin or monoclonal antibody in IgG class or IgG1 subclass.
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Inventors:
ANSONII EI MAGUNIN
POO-SHINGU WAFU
POORU DENISU
POO-SHINGU WAFU
POORU DENISU
Application Number:
JP29541987A
Publication Date:
March 30, 1989
Filing Date:
November 25, 1987
Export Citation:
Assignee:
CONNAUGHT LAB
International Classes:
A61K39/395; A61K9/08; A61K38/16; A61L2/00; C07K16/06; A61K38/00; (IPC1-7): A61K9/08; A61K39/395
Attorney, Agent or Firm:
Wakabayashi Tadashi