To obtain the subject new compound comprising a specific sterol compound capable of efficiently and stereoselectively synthesizing by organic synthetic chemical method, having excellent in vivo antitumor action and useful as a medicine such as anticancer agent.
This new sterol compound is represented by formula I (R is nonyl or decyl) and has excellent in vivo antiulcer action and is capable of stereoselectively synthesizing by organic synthetic chemical method and is useful as a medicine, etc., e.g. anticancer agent. The compound is obtained by using 3β,12β-dihydroxy-5 α-pregnan20 one as a starting material, protecting the hydroxyl group, reacting the compound with a Grignard feagent to afford a substance having alcohol at 20 position, dehydrating the substance to provide 20,22(E)-olefin substance of formula of formula III, oxidizing the substance to afford 20,22-epoxy substance, protecting hydroxyl group, subjecting the epoxy substance to hydrochloric acid treatment, oxidizing the resultant 3β,12β-diacetoxyallyl alcohol substance of formula IV to provide 20,21-epoxy substance and deprotecting the resultant substance.
WADA HISAYA
YAMADA TAIJI
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