Title:
SUBSTITUTED 2-(2,6-DIOXOPIPERIDIN-3-YL)PHTHALIMIDES AND 1-OXOISOINDOLINES, AND METHOD OF REDUCING TNF-α LEVELS
Document Type and Number:
Japanese Patent JP2015131863
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxoisoindolines, and a method of reducing TNF-α levels.SOLUTION: Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF-α in a mammal. Specific embodiments include 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.
Inventors:
MULLER GEORGE W
STIRLING DAVID I
ROGER SHEN-CHU CHEN
STIRLING DAVID I
ROGER SHEN-CHU CHEN
Application Number:
JP2015088425A
Publication Date:
July 23, 2015
Filing Date:
April 23, 2015
Export Citation:
Assignee:
CELGENE CORP
International Classes:
C07D401/04; A61K31/4439; A61K31/445; A61P1/00; A61P1/04; A61P7/00; A61P9/04; A61P9/10; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/00; A61P19/02; A61P25/00; A61P29/00; A61P31/04; A61P31/08; A61P31/18; A61P31/22; A61P33/02; A61P33/06; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P39/02; A61P43/00
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Mami Hino
Yoshimitsu Maki
Yasuhito Suzuki
Norio Omori
Mami Hino
Yoshimitsu Maki
Yasuhito Suzuki
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