Title:
SUBSTITUTED 6,6-HETEROBICYCLIC DERIVATIVE
Document Type and Number:
Japanese Patent JP2004203751
Kind Code:
A
Abstract:
To provide an corticotropin releasing factor (hormone) CRF (CRH) antagonist useful for Alzheimer's disease and obesity.
The substituted 6,6-heterobicyclic derivative is represented by formula I [wherein, A denotes an N or a CR7, B denotes an NR1R2, a CR1R2R10, an OCR1R2R10 or the like; G denotes an N or a CR4; K denotes an O, an S, a C=OR6R12, an NR5 or the like; D and E denote each a C=O, an S, an O, a CR4R6, an NR8 or the like], e.g. 8-(1-ethylpropoxy)-6-methyl-4-(2,4,6-trimethylphenyl)-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one. A medicinal composition comprises the substituted 6,6-heterobicyclic derivative represented by formula I.
Inventors:
CHEN YUHPYNG LIANG
Application Number:
JP2002371663A
Publication Date:
July 22, 2004
Filing Date:
December 24, 2002
Export Citation:
Assignee:
PFIZER
International Classes:
A61K31/4375; A61K31/47; A61K31/4706; A61K31/4709; A61K31/4985; A61K31/519; A61P1/00; A61P1/04; A61P1/06; A61P1/12; A61P1/14; A61P3/04; A61P5/10; A61P5/14; A61P9/04; A61P9/12; A61P11/06; A61P13/10; A61P15/06; A61P15/08; A61P17/06; A61P19/02; A61P19/10; A61P21/02; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P29/00; A61P29/02; A61P31/18; A61P35/00; A61P37/00; A61P37/08; C07D215/42; C07D405/12; C07D471/04; C07D475/02; C07D215/22; (IPC1-7): C07D215/22; A61K31/4375; A61K31/47; A61K31/4706; A61K31/4709; A61K31/4985; A61K31/519; A61P1/00; A61P1/04; A61P1/06; A61P1/12; A61P1/14; A61P3/04; A61P5/10; A61P5/14; A61P9/04; A61P9/12; A61P11/06; A61P13/10; A61P15/06; A61P15/08; A61P17/06; A61P19/02; A61P19/10; A61P21/02; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P29/00; A61P29/02; A61P31/18; A61P35/00; A61P37/00; A61P37/08; C07D215/42; C07D405/12; C07D471/04; C07D475/02
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Tadahiko Kurita
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Tadahiko Kurita
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