Title:
SUBSTITUTED HYDROXAMIC ACID COMPOUNDS
Document Type and Number:
Japanese Patent JP2019077688
Kind Code:
A
Abstract:
To provide substituted hydroxamic acid compounds, and in particular, UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine deacetylase (LpxC), and methods of using such compounds to treat Gram-negative bacteria infections.SOLUTION: There are disclosed compounds of formulas (I) and (II), and pharmaceutically acceptable salts thereof, where the variables, R, R, R, R, R, R, R, R, R, R, R, D, Q, Y, X, X, Xand Xare defined herein. These compounds are useful for treating Gram-negative bacteria infections.SELECTED DRAWING: None
Inventors:
ZHOU PEI
ERIC J TOONE
ROBERT A NICHOLAS
ERIC J TOONE
ROBERT A NICHOLAS
Application Number:
JP2018224004A
Publication Date:
May 23, 2019
Filing Date:
November 29, 2018
Export Citation:
Assignee:
UNIV DUKE
UNIV OF NORTH CAROLINA
UNIV OF NORTH CAROLINA
International Classes:
C07C259/06; A61K31/16; A61K31/415; A61K31/4412; A61K31/495; A61K31/5375; A61P31/04; C07C317/24; C07C317/28; C07D213/64; C07D231/12; C07D295/155
Domestic Patent References:
| JP2006519772A | 2006-08-31 | |||
| JP2000344752A | 2000-12-12 | |||
| JP6458270B2 | 2019-01-30 | |||
| JP2012502946A | 2012-02-02 | |||
| JP2013100277A | 2013-05-23 | |||
| JP2005516061A | 2005-06-02 | |||
| JP2013507434A | 2013-03-04 |
Foreign References:
| WO2014142298A1 | 2014-09-18 | |||
| WO2013170165A1 | 2013-11-14 | |||
| WO2012031298A2 | 2012-03-08 | |||
| WO2011132712A1 | 2011-10-27 | |||
| WO2013049255A1 | 2013-04-04 | |||
| WO2012143340A1 | 2012-10-26 |
Other References:
CHEMISTRY - AN ASIAN JOURNAL, vol. 4(11), JPN6019041736, 2009, pages 1668 - 1672, ISSN: 0004142540
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23(8), JPN6019041738, 2013, pages 2362 - 2367, ISSN: 0004142539
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23(8), JPN6019041738, 2013, pages 2362 - 2367, ISSN: 0004142539
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kazumi Nakamura
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kazumi Nakamura