Title:
置換ケト-エナミンの製造方法
Document Type and Number:
Japanese Patent JP4172660
Kind Code:
B2
Abstract:
The present invention discloses a process for the preparation of a compound having formula 4: The process comprises the step of reacting an enolate having the formula: with a Grignard reagent. The enolate salt is formed in situ from the reaction of a protected ester wherein M is an alkali metal. R6 and R7 are each hydrogen or are independently selected from wherein Ra and Rb are independently selected from hydrogen, lower alkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, lower alkyl, trifluoromethyl, alkoxy, halo and phenyl; and wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from lower alkyl, trifluoromethyl, alkoxy and halo. Alternatively, R6 is as defined above and R7 is R12OC(O)- wherein R12 is benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded form wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, lower alkyl, alkoxy, halogen and trifluoromethyl.
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Inventors:
Hate, Anthony Earl
Stack, Timothy El
Menjia, The Jerome A
Stack, Timothy El
Menjia, The Jerome A
Application Number:
JP50077399A
Publication Date:
October 29, 2008
Filing Date:
May 19, 1998
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
C07C221/00; C07C225/14; C07C225/16
Domestic Patent References:
| JP8295662A | ||||
| JP9504024A |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
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