SUBSTRATES FOR HIGH-DENSITY CELL GROWTH AND METABOLITE EXCHANGE

Japanese Patent JP2022068206

A

To provide: a high-density cell growth device for achieving a high ratio of the surface area to the volume, maintaining adequate metabolite transport within a system, and maintaining shear forces experienced by cells below lethal levels; and methods of manufacture and use.SOLUTION: A polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one another with a multitude of tiny micropillars or other spacers extending between them, keeping the bag at a predetermined thickness and preventing the bag from collapsing and the sides from sticking together. In other embodiments, the sides are held apart by gas pressure alone. A 0.01 μm to 1000 μm parylene or other biocompatible coating over the bag outsides controls the permeability of the bag material and provides a bio-safe area for cell growth.SELECTED DRAWING: None

TAI YU-CHONG
LIU YAN
COLIN A COOK
FONG YUMAN
CHEN NANHAI G

JP2022014949A

May 09, 2022

February 02, 2022

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CALIFORNIA INST OF TECHN
HOPE CITY

C12M1/00; B29D22/00; C12N5/07; C12N7/00

JP2001521370A	2001-11-06
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JPH05184351A	1993-07-27
JPH0310675A	1991-01-18
JP2005323588A	2005-11-24
JP2012040033A	2012-03-01
JPS62228269A	1987-10-07

EP0725134A2	1996-08-07
US20120040453A1	2012-02-16
WO2012170878A2	2012-12-13
WO2016027800A1	2016-02-25
WO1997021347A1	1997-06-19
US20140227769A1	2014-08-14

Kenji Sugimura
Mitsutsugu Sugimura
Masaki Kato

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