SULFAMOYL-ARYLAMIDES AND USE THEREOF AS MEDICAMENTS FOR TREATMENT OF HEPATITIS B

Japanese Patent JP2021176846

A

To provide HBV inhibitors that have additional advantages such as increased potency or an increased safety window.SOLUTION: There are provided sulfamoyl aryl amides represented by following formula, a stereoisomer or a tautomeric form thereof, or a pharmaceutically acceptable salt or a solvate thereof, a pharmaceutical composition containing these inhibitors, and their use, alone or in combination with other HBV inhibitors, in HBV therapy. (In the formula, B represents a monocyclic 5 to 6 membered aromatic ring, optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N.)SELECTED DRAWING: None

KOEN VANDYCK
STEFAAN JULIEN LAST
GEERT ROMBOUTS
WIM GASTON VERSCHUEREN
PIERRE JEAN-MARIE BERNARD RABOISSON

JP2021095380A

November 11, 2021

June 07, 2021

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JANSSEN SCIENCES IRELAND UC

C07C311/16; A61K31/18; A61K31/277; A61K31/337; A61K31/34; A61K31/341; A61K31/351; A61K31/381; A61K31/397; A61K31/40; A61K31/4015; A61K31/4164; A61K31/426; A61K31/438; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4453; A61K31/4468; A61K31/45; A61K31/4525; A61K31/4535; A61K31/454; A61K31/495; A61K31/5375; A61K31/55; A61P31/20; C07C311/17; C07C311/20; C07C311/50; C07D205/04; C07D207/14; C07D207/273; C07D207/36; C07D211/28; C07D211/56; C07D211/58; C07D211/76; C07D211/96; C07D213/42; C07D213/81; C07D213/82; C07D233/90; C07D277/56; C07D295/13; C07D295/26; C07D305/08; C07D307/22; C07D307/68; C07D309/14; C07D333/38; C07D333/48; C07D407/12; C07D491/107; C07D491/113; C07D493/08

Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Yasuhito Suzuki

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