SUSPENSION FORMULATIONS OF INSULINOTROPIC PEPTIDES AND USES THEREOF

Title:

SUSPENSION FORMULATIONS OF INSULINOTROPIC PEPTIDES AND USES THEREOF

Document Type and Number:

Japanese Patent JP2014040420

Kind Code:

A

Abstract:

To provide an osmotic delivery device of a suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide).

In a device arrangement and a method for delivering a suspension formulation, the suspension formulation comprises (i) a non-aqueous, single-phase vehicle comprising one or more polymers and one or more solvents and exhibiting viscous fluid characteristics, and (ii) a particle formulation comprising the insulinotropic peptide dispersed in the vehicle, where the particle formulation further includes a stabilizing component comprising one or more stabilizers, e.g., carbohydrates, antioxidants, amino acids and buffers.

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Inventors:

ALESSI THOMAS R
RYAN D MERCER
CATHERINE M ROHLOFF
BING YANG

Application Number:

JP2013173812A

Publication Date:

March 06, 2014

Filing Date:

August 23, 2013

Export Citation:

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Assignee:

INTARCIA THERAPEUTICS INC

International Classes:

A61K38/00; A61K9/10; A61K47/12; A61K47/14; A61K47/18; A61K47/22; A61K47/26; A61K47/32; A61P3/10; C07K14/605

Domestic Patent References:

JP5351884B2

2013-11-27

Foreign References:

WO2006083761A2	2006-08-10
WO2006111169A1	2006-10-26
WO2006084139A2	2006-08-10
WO2006131730A1	2006-12-14

Attorney, Agent or Firm:

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Masaru Nakajima

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