Title:
対称的に二置換された芳香族化合物及びポリ(ADP-リボース)グリコヒドロラーゼを阻害するための医薬組成物、及びそれらの使用方法
Document Type and Number:
Japanese Patent JP2004531474
Kind Code:
A
Abstract:
Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
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Inventors:
Li, Jiahe
Ferraris, Dana Buoy.
Cletree, Paul W.
Re-wacing
Wang, Eric Yang Jun
Thing, Amy Dee.
Shoe, Weizing
Tsang, Gee
Ferraris, Dana Buoy.
Cletree, Paul W.
Re-wacing
Wang, Eric Yang Jun
Thing, Amy Dee.
Shoe, Weizing
Tsang, Gee
Application Number:
JP2002557893A
Publication Date:
October 14, 2004
Filing Date:
April 10, 2001
Export Citation:
Assignee:
Guilford Pharmaceuticals,Inc.
International Classes:
C07D295/10; A61K9/10; A61K9/107; A61K9/20; A61K9/48; A61K31/136; A61K31/166; A61K31/18; A61K31/216; A61K31/277; A61K31/352; A61K31/39; A61K31/4025; A61K31/444; A61K31/4545; A61K31/496; A61K31/5377; A61K47/30; A61P1/00; A61P1/04; A61P3/00; A61P3/10; A61P7/00; A61P9/00; A61P9/10; A61P13/12; A61P17/00; A61P17/02; A61P19/02; A61P19/10; A61P21/04; A61P25/00; A61P25/02; A61P27/02; A61P29/00; A61P31/04; A61P37/04; A61P43/00; C07C69/00; C07C69/76; C07C211/45; C07C225/16; C07C233/65; C07C233/66; C07C233/69; C07C233/73; C07C255/46; C07C311/37; C07C311/46; C07D207/325; C07D213/30; C07D213/40; C07D295/12; C07D295/13; C07D295/18; C07D295/192; C07D311/82; C07D311/86; C07D327/08; C07D411/12; C07D411/14; C07D207/32; (IPC1-7): C07C69/76; A61K9/10; A61K9/107; A61K9/20; A61K9/48; A61K31/136; A61K31/166; A61K31/18; A61K31/216; A61K31/277; A61K31/352; A61K31/39; A61K31/4025; A61K31/444; A61K31/4545; A61K31/496; A61K31/5377; A61K47/30; A61P1/04; A61P3/10; A61P7/00; A61P9/00; A61P9/10; A61P13/12; A61P17/00; A61P17/02; A61P19/02; A61P19/10; A61P21/04; A61P25/00; A61P25/02; A61P27/02; A61P29/00; A61P31/04; A61P37/04; A61P43/00; C07C211/45; C07C233/65; C07C233/66; C07C233/73; C07C255/46; C07C311/37; C07D213/30; C07D213/40; C07D295/10; C07D295/12; C07D295/18; C07D311/82; C07D311/86; C07D327/08; C07D411/14
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Masaya Nishiyama