Title:
SYNTHESIS OF 6,6-DISUBSTITUTED DIHYDROPTERIDINE
Document Type and Number:
Japanese Patent JP2529092
Kind Code:
B2
Abstract:
PURPOSE: To synthesize the compound for the treatment of Parkinson's disease or the like by oxidizing a 6-(2-amino-2,2-disubstituted ethylamino)-5-amino- pyrimidine to form an 5-imine and then condensing it after hydrolysis.
CONSTITUTION: The target compound of formula II or formula III (Q1 and Q2 are each O or HR6) is synthesized by oxidizing a 6-(2-amino-2,2-disubstituted ethylamino)-5-amino-pyrimidine of formula I (R1 and R2 are each H, hydroxy, 1-4C alkynyl or the like; R3 and R4 are each 1-12C alkyl, 2-7C alkenyl, 2-7C alkynyl or the like; R5 is H, 1-6C alkyl, 1-7C cycloalkyl or the like) with a halogen (e.g. bromide or iodine) to form an 5-imine and then condensing it after the hydrolysis using a dithionite or a hydrogen in the presence of a catalytic amount of palladium.
Inventors:
Ayling, June
Bailey, Steven
Bailey, Steven
Application Number:
JP7805594A
Publication Date:
August 28, 1996
Filing Date:
March 24, 1994
Export Citation:
Assignee:
SOUTH ALABAMA MEDICAL SCI FOUND
International Classes:
A61K31/505; A61K31/519; A61P25/00; A61P25/24; A61P25/26; A61P43/00; C07D239/42; C07D239/47; C07D239/48; C07D239/50; C07D401/12; C07D475/00; C07D475/04; (IPC1-7): C07D475/04; A61K31/505; C07D239/48; C07D475/00