SYNTHESIS AND COMPOSITION OF 2'-TERMINATOR NUCLEOTIDE

Title:

SYNTHESIS AND COMPOSITION OF 2'-TERMINATOR NUCLEOTIDE

Document Type and Number:

Japanese Patent JP2011224016

Kind Code:

A

Abstract:

To provide novel nucleotides and/or nucleosides having blocking groups at 2'-positions of sugar moieties.

The invention provides compositions that comprise the nucleotides and/or nucleosides having blocking groups at 2'-positions of sugar moieties. Methods of synthesizing these nucleic acids are also provided.

Inventors:

GELFAND DAVID HARROW
BODEPUDI VEERAIAH
WILL STEPHEN GORDON

Application Number:

JP2011168158A

Publication Date:

November 10, 2011

Filing Date:

August 01, 2011

Export Citation:

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Assignee:

HOFFMANN LA ROCHE

International Classes:

A61K31/513; C12N15/09; A61K31/522; A61K31/7072; A61K31/7076; C07H19/00; C07H19/06; C07H19/16; C07H21/04; C07H23/00; C12Q1/68

Domestic Patent References:

JPH03178985A	1991-08-02
JPH08509857A	1996-10-22

Foreign References:

EP0252683A2	1988-01-13
US20040005599A1	2004-01-08

Other References:

JPN6010034624; Ｂｉｏｃｈｉｍｉｃａ　ｅｔ　Ｂｉｏｐｈｙｓｉｃａ　Ａｃｔａ７１９, 1982, ２１５-２２２
JPN6010034616; Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ．　ＵＳＡ７８, 1981, ３３６８-３３７２
JPN6010034618; Ｎｕｃｌｅｉｃ　Ａｃｉｄｓ　Ｒｅｓ．２５, 1997, ４５００-４５０４
JPN6010034620; Ｎｕｃｌｅｉｃ　Ａｃｉｄｓ　Ｒｅｓ．２０, 1992, ２４７１-２４８３
JPN6010034626; Ａｌｆｒｅｄ　Ｂｅｎｚｏｎ　Ｓｙｍｐ．９, 1976, ２７９-２９１
JPN6010034621; Ｏｒｉｇ．　Ｌｉｆｅ　Ｅｖｏｌ．　Ｂｉｏｓｐｈ．３２, 2002, ２１９-２２４
JPN6010034623; Ｊ．　Ｏｒｇ．　Ｃｈｅｍ．３５, 1970, ２８８１-２８８３

Attorney, Agent or Firm:

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima

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