Title:
Ｔ細胞受容体
Document Type and Number:
Japanese Patent JP7179616
Kind Code:
B2
Abstract:
The present invention relates to T cell receptors (TCRs) which bind the HLA-A*0201 restricted peptide GVYDGEEHSV (SEQ ID NO: 1) derived from the MAGE-B2 protein. The TCRs of the invention demonstrate excellent specificity profiles for this MAGE epitope. Also provided are nucleic acids encoding the TCRs, cells engineered to present the TCRs, cells harbouring expression vectors encoding the TCRs and pharmaceutical compositions comprising the TCRs, nucleic acids or cells of the invention.
Inventors:
Tribble, Nicholas
Lawrence, william
Bag, Eleanor
Lawrence, william
Bag, Eleanor
Application Number:
JP2018552696A
Publication Date:
November 29, 2022
Filing Date:
April 10, 2017
Export Citation:
Assignee:
Adaptune Mune Limited
International Classes:
C07K14/725; A61K35/17; A61K38/17; A61K48/00; A61P35/00; A61P37/04; C12N5/0783; C12N5/10; C12N15/12
Domestic Patent References:
| JP2004536590A | ||||
| JP2012529283A | ||||
| JP2019513383A | ||||
| JP2019516356A | ||||
| JP2019516357A |
Attorney, Agent or Firm:
Okuyama Shoichi
Nakamura Ayako
Soji Morimoto
Akiko Mizushima
Kohei Arihara
Nakamura Ayako
Soji Morimoto
Akiko Mizushima
Kohei Arihara