Title:
【発明の名称】修飾一本鎖オリゴヌクレオチドを使用した標的染色体ゲノム変換
Document Type and Number:
Japanese Patent JP2003528607
Kind Code:
A
Abstract:
Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2'-O-Me base analogs.
Inventors:
Kumiek, Eric Bee.
Gunper, Howard Bee.
Rice, Michael Sea.
Gunper, Howard Bee.
Rice, Michael Sea.
Application Number:
JP2001570719A
Publication Date:
September 30, 2003
Filing Date:
March 27, 2001
Export Citation:
Assignee:
UNIVERSITY OF DELAWARE
International Classes:
A61K31/7088; A61K31/712; A61K31/7125; A61K48/00; A61P1/16; A61P3/06; A61P7/04; A61P7/06; A61P25/28; A61P35/00; A61P43/00; C12N5/10; C12N15/10; C12N15/113; C12N15/09; C12Q1/68; A61K38/00; (IPC1-7): C12N15/09; A61K31/7088; A61K31/712; A61K31/7125; A61K48/00; A61P1/16; A61P3/06; A61P7/04; A61P7/06; A61P25/28; A61P35/00; A61P43/00; C12N5/10; C12Q1/68
Foreign References:
| WO1999014226A2 | 1999-03-25 | |||
| WO1999058702A1 | 1999-11-18 |
Other References:
HUM. MOL. GENET., vol. 4, no. 11, JPN6010072958, 1995, pages 2081 - 2087, ISSN: 0001805292
PROC. NATL. ACAD. SCI. USA, vol. 92, JPN6010072960, 1995, pages 8298 - 8302, ISSN: 0001805293
NAT. BIOTECHNOL., vol. 17, JPN6010072961, 1999, pages 989 - 993, ISSN: 0001805294
J. BIOL. CHEM., vol. 274, no. 17, JPN6010072963, 1999, pages 11541 - 11548, ISSN: 0001805295
PROC. NATL. ACAD. SCI. USA, vol. 92, JPN6010072960, 1995, pages 8298 - 8302, ISSN: 0001805293
NAT. BIOTECHNOL., vol. 17, JPN6010072961, 1999, pages 989 - 993, ISSN: 0001805294
J. BIOL. CHEM., vol. 274, no. 17, JPN6010072963, 1999, pages 11541 - 11548, ISSN: 0001805295
Attorney, Agent or Firm:
Shusaku Yamamoto (2 outside)