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Patent Searching and Data


Title:
TAXOL ANALOG AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JPH10139714
Kind Code:
A
Abstract:

To provide a new analog of taxol known as an anticancer agent and producible in a high yield without using a reagent having safety problem such as heavy metal.

This compound is expressed by the formula I [X is H or a (substituted)methyl; Y and Z are each Z, OR5 (R5 is H, an alkyl, etc.), etc.; R1 is H, OR6 (R6 is R5), etc.; R2 is H, OR7 (R7 is R5), etc.; R3 is H or OR8 (R8 is R5)], e.g. the compound of the formula II. The compound of the formula I can be produced by reacting a compound of the formula III (R4 is an alkoxyalkyl or a trialkylsilyl; W is an eliminable group) with an alkali metal amide, treating the resultant compound of the formula IV with an acid to obtain a compound of the formula V and reacting the product with a base.


Inventors:
TAKAHASHI TAKASHI
Application Number:
JP30019296A
Publication Date:
May 26, 1998
Filing Date:
November 12, 1996
Export Citation:
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Assignee:
KURARAY CO
International Classes:
C07C45/44; C07C49/643; C07C49/737; C07C49/753; C07C69/02; C07F7/18; C07D305/14; (IPC1-7): C07C49/643; C07C45/44; C07C49/737; C07C49/753; C07C69/02; C07D305/14; C07F7/18