Title:
TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING NON-SPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIANT DOMAINS
Document Type and Number:
Japanese Patent JP2022031790
Kind Code:
A
Abstract:
To provide ISVs related to an assay that can be used to predict whether a given ISV will be subject to protein interference and/or give rise to a (non-specific) signal in assays (for example an ADA immunoassay).SOLUTION: Provided is a protein, polypeptide or other biological agent comprising at least one immunoglobulin single variable domain (ISV) that binds to a target of treatment and at least one ISV that binds to serum albumin, where the target-binding ISV has a C terminal of specific sequence, where the ISV is a VHH, sequence-optimized VHH, humanized VHH or camelized VHH, or an ISV comprising a VH sequence other than the VHH, sequence-optimized VHH, humanized VHH and camelized VHH, or an ISV derived from a VH sequence.SELECTED DRAWING: None
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Inventors:
JUDITH BAUMEISTER
MARIE-PAULE LUCIENNE ARMANDA BOUCHE
CARLO BOUTTON
MARIE-ANGE BUYSE
VEERLE SNOECK
STEPHANIE STAELENS
MARIE-PAULE LUCIENNE ARMANDA BOUCHE
CARLO BOUTTON
MARIE-ANGE BUYSE
VEERLE SNOECK
STEPHANIE STAELENS
Application Number:
JP2021191076A
Publication Date:
February 22, 2022
Filing Date:
November 25, 2021
Export Citation:
Assignee:
ABLYNX NV
International Classes:
C07K16/18; A61K38/02; A61K39/395; A61K45/00; A61K47/68; A61P3/00; C07K16/46
Domestic Patent References:
| JP2007008925A | 2007-01-18 | |||
| JP2006523090A | 2006-10-12 |
Foreign References:
| WO2009127691A1 | 2009-10-22 | |||
| WO2008068280A1 | 2008-06-12 |
Other References:
SKOTTRUP P.D. ET AL.: "Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromo", ANAL. BIOCHEM. [ONLINE], vol. 415 [Epub 2011 Apr 20], JPN6016015687, pages 158 - 167, ISSN: 0004996054
Attorney, Agent or Firm:
Patent business corporation Tsukuni