Title:
TERPENOID LACTONE COMPOUND AND MANUFACTURE OF THE SAME
Document Type and Number:
Japanese Patent JP3512155
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new terpenoid lactone compound having an excellent activity to tumor necrotizing factor(TNF) and interleukin I(IL-1) biosynthesis inhibition.
SOLUTION: This compound is expressed in formula (the dotted line is an optional bond; R1 is O or OH; X is O, N or the like; R2 is H, an 1 to 5C alkyl or the like; R3 is H, OH or an 1 to 4C alkylthio or the like; R4 is H, an 1 to 5C alkoxy or the like; R5 is H, an 1 to 4C alkylthio or the like; R6 is H or the like; R7 and R8 form a lactone ring with their bonding C). For example, [5bS-(1aR*, 5bβ, 8aα, 8bα, 10aα, 10bβ)]-5b,6,7,8,8a,8b,10a,10b-octahydro-2- hydroxy-5b,8b-dimethyl-2H,4H,9H-furo[2',3',4',:4,5]oxileno[2,3]naphto[2,1- c]pyrane-4,9-dione. The compound of the formula is obtained by culturing Oidiodendron griseum (FERM BP-5778) or their variant or recombinant.
Inventors:
Ichikawa, Katsuomi
Ikenaka, Masaya
Kojima, Nakao
Nishida, Hiroyuki
Yoshikawa, Nobuji
Ikenaka, Masaya
Kojima, Nakao
Nishida, Hiroyuki
Yoshikawa, Nobuji
Application Number:
JP2019799A
Publication Date:
March 29, 2004
Filing Date:
January 28, 1999
Export Citation:
Assignee:
PFIZER PHARMACEUT INC
International Classes:
A61K31/00; A61K31/365; A61K31/366; A61K31/47; A61K31/4738; A61K31/4741; A61P1/00; A61P9/00; A61P9/10; A61P11/00; A61P29/00; A61P43/00; C07D307/92; C07D311/92; C07D491/06; C07D491/16; C12P17/06; C07D491/20; C07D493/06; C07D493/20; C12P17/12; C12R1/645; (IPC1-7): C07D311/92; A61K31/366; A61K31/4741; A61P1/00; A61P9/10; A61P11/00; A61P29/00; A61P43/00; C07D491/16; C07D493/06; C12P17/06; C12P17/12
Attorney, Agent or Firm:
室伏 良信