Title:
心臓障害の治療に用いられる第三級アミン
Document Type and Number:
Japanese Patent JP6397398
Kind Code:
B2
Abstract:
The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP185) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl)amine structure.
Inventors:
Tusken, Ketyl
Riglen, Bargitte
Ostensen, Ellen
Clavenes, Jo
Riglen, Bargitte
Ostensen, Ellen
Clavenes, Jo
Application Number:
JP2015512079A
Publication Date:
September 26, 2018
Filing Date:
May 17, 2013
Export Citation:
Assignee:
Universitite I Oslo
International Classes:
A61K31/426; A61K31/137; A61K31/17; A61K31/197; A61K31/24; A61K31/343; A61K31/41; A61K31/4409; A61P9/00; A61P9/04; A61P9/10; A61P43/00; C07C211/27; C07C211/29; C07C211/49; C07C211/53; C07C217/58; C07C229/38; C07C275/40; C07D213/38; C07D257/04; C07D277/28; C07D277/56; C07D307/78
Domestic Patent References:
| JP57122048A | ||||
| JP2010138199A | ||||
| JP62252746A | ||||
| JP49006302B1 | ||||
| JP53030701B1 | ||||
| JP8217731A | ||||
| JP2007119435A | ||||
| JP2002516906A | ||||
| JP63302364A |
Foreign References:
| WO2000027852A1 | ||||
| WO1999065864A1 | ||||
| DE2050999A | ||||
| US3823117 | ||||
| CN1865221A | ||||
| WO2010010359A1 | ||||
| WO2004048463A1 | ||||
| WO2012080762A1 |
Other References:
CHINGAKHAM B. SINGH,AQUEOUS-MEDIATED N-ALKYLATION OF AMINES,EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2007年 3月,V2007 N8,P1369-1377
JOURNAL OF ORGANIC CHEMISTRY,2002年,Vol. 67,pp. 7091-7095
Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft,1962年,Vol. 295,pp. 871-879
JOURNAL OF CHEMICAL RESEARCH, SYNOPSES,1998年,pp. 302-303
REGISTRY(STN)[online],2008.09.10[検索日 2017.02.21]CAS登録番号 1048241-53-7
REGISTRY(STN)[online],2008.09.10[検索日 2017.02.21]CAS登録番号 1048165-44-1
JOURNAL OF ORGANIC CHEMISTRY,2002年,Vol. 67,pp. 7091-7095
Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft,1962年,Vol. 295,pp. 871-879
JOURNAL OF CHEMICAL RESEARCH, SYNOPSES,1998年,pp. 302-303
REGISTRY(STN)[online],2008.09.10[検索日 2017.02.21]CAS登録番号 1048241-53-7
REGISTRY(STN)[online],2008.09.10[検索日 2017.02.21]CAS登録番号 1048165-44-1
Attorney, Agent or Firm:
Patent corporation ssinpat
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