Title:
細胞内ターゲッティングのための硫酸化デンドリマーを有する治療複合体
Document Type and Number:
Japanese Patent JP6634547
Kind Code:
B2
Abstract:
The present invention relates to novel dendrimer conjugates, methods for their preparation and their use for treatment of diseases. The invention discloses a new method for the delivery of dendrimer conjugates with therapeutically active molecules into the cell by utilizing transmembrane solute carrier proteins enabling uptake of the inventive dendrimer conjugates. Particular subject-matter of the present invention is a conjugate of the formula E-[G-L-D(OSO3-M+)n]m, wherein E is a therapeutic or diagnostic effector molecule, wherein D(OSO3-M+)n is a dendrimer D carrying a number n of sulfate groups OSO3-M+, wherein the number n of sulfate groups is selected from 6 to 96, wherein M is a cationic inorganic or organic counter ion to the anionic sulfate group, wherein L is a linker or spacer between D and E, wherein G is a connecting functional group forming the attachment between L and E, and wherein m is an integer from 1 to 20.
Inventors:
Kairicha
Michael sealner
Michael sealner
Application Number:
JP2016568808A
Publication Date:
January 22, 2020
Filing Date:
May 21, 2015
Export Citation:
Assignee:
ICD-Therapeutics Gezel Shaft Mitt Beschlenktel Haftung
International Classes:
C07D207/00; A61K31/537; A61K31/553; A61K31/7088; A61K38/02; A61K38/16; A61K38/38; A61K38/46; A61K38/50; A61K39/395; A61K45/00; A61K47/34; A61K47/59; A61K47/60; A61P3/00; A61P3/10; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07C43/04; C07C381/00; C07D209/00; C07D213/00; C08G65/326
Domestic Patent References:
| JP2011516415A | ||||
| JP2013518841A |
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Michiko Uehara
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Michiko Uehara