Title:
THROMBIN RECEPTOR ANTAGONIST
Document Type and Number:
Japanese Patent JP2007056043
Kind Code:
A
Abstract:
To provide a compound that is useful as a thrombin antagonist and bonds to cannabinoid (CB2) receptors and provide a compound that is useful for the following treatments.
This compound is a heterocyclic substituted compound or a pharmaceutically acceptable salt thereof, represented by formula (I)(wherein Z is -(CH2)n-; (a); (b), wherein R10 is absent or (c) wherein R3 is absent; the single dotted line represents an optional double bond; the double dotted line represents an optional single bond; n is 0 to 2; Het is, as needed, an optionally substituted mono-, bi-, tricyclic heteroaromatic group; X is -O- or -NR6-, when the double dotted line represents a single bond; in addition, X is H or -OH or -NHR20, when the bond is absent).
Inventors:
CHACKALAMANNIL SAMUEL
CHELLIAH MARIAPPAN
XIA YAN
CHELLIAH MARIAPPAN
XIA YAN
Application Number:
JP2006329955A
Publication Date:
March 08, 2007
Filing Date:
December 06, 2006
Export Citation:
Assignee:
SCHERING PLOUGH CORP
International Classes:
C07D405/06; A61K31/443; A61K31/4436; A61K31/4439; A61K31/444; A61K31/497; A61P1/04; A61P3/10; A61P7/02; A61P9/00; A61P9/02; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P11/16; A61P13/12; A61P19/02; A61P19/10; A61P25/00; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D521/00
Domestic Patent References:
| JP2002509146A | 2002-03-26 | |||
| JP2004503551A | 2004-02-05 |
Foreign References:
| WO1999026943A1 | 1999-06-03 | |||
| US6063847A | 2000-05-16 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita