5'-NUCLEOTIDASE-RESISTANT DERIVATIVE OF IMMUNOPOTENTIATING INOSINE-MONOPHOSPHATE AND USE THEREOF

Title:

5'-NUCLEOTIDASE-RESISTANT DERIVATIVE OF IMMUNOPOTENTIATING INOSINE-MONOPHOSPHATE AND USE THEREOF

Document Type and Number:

Japanese Patent JP2007056044

Kind Code:

A

Abstract:

To provide a 5'-nucleotidase-resistant derivative of immunopotentiating inosine-mono-phosphoric acid that has more larger immunopotentiating activity, higher stability and resistance to 5'-nucleotidase.

This invention relates to 5'-nucleotidase-resistant inosine-5'-monophosphoric acid and a method for producing the derivative and inosine-5'-monophosphoric acid is chemically changed to a compound represented by formula (I) (wherein R is selected from the group consisting of an alkyl, an alkoxy and secondary amino compound) and the biological activity of the inosine-5'-monophosphoric acid is allowed to retain in vivo.

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Inventors:

HADDEN JOHN W
GINER SOROLLA ALFREDO
MASIHI NOEL K

Application Number:

JP2006330014A

Publication Date:

March 08, 2007

Filing Date:

December 06, 2006

Export Citation:

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Assignee:

UNIV SOUTH FLORIDA

International Classes:

A61K45/00; A61P37/04; A61P43/00; A61K31/7076

Attorney, Agent or Firm:

Hidesaku Yamamoto

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