【発明の名称】分枝鎖アミノ酸依存アミノトランスフェラーゼ阻害剤および糖尿病性網膜症の治療におけるそれらの使用

Japanese Patent JP2003516379

A

The present invention is directed to a method for the prophylactic and therapeutic treatment of diabetic retinopathy. The method involves the administration of an inhibitor of formulae (I), (II) and (III) of the branch chain amino acid-dependent aminotransferase (BCAT) pathway to an animal, such as a mammal, in particular a human, in an amount sufficient to treat the retina for diabetic retinopathy prophylactically or therapeutically. The present invention is also directed to several novel inhibitors of formula (IV) of the BCAT pathway. In formulae (I-IV), n, m, X and R1-R13 have the meanings given in the description.

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Justin Stephen Bryans
Rain-Yen Who
Susan M. Hatsun
Kathryn Follie Ranu
Eric Reese
Mycle Francis Lafferty
Todd Robert Ryder
Tee-twee
Devin Franklin Welty
David Juagen Wustrow

JP2001543493A

May 13, 2003

November 08, 2000

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Warner-Lambert Company
The Penn State Research Foundation
Wake Forest University

A61K31/19; A61K31/194; A61K31/195; A61K31/27; A61P3/10; A61P9/10; A61P25/00; A61P25/08; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P43/00; C07C55/28; C07C59/11; C07C59/62; C07C229/10; C07C229/14; C07C229/18; C07C229/22; C07C229/28; C07C229/34; C07C233/08; A61P1/04; C07C233/47; C07C271/22; (IPC1-7): C07C55/28; A61K31/19; A61K31/194; A61K31/195; A61K31/27; A61P1/04; A61P3/10; A61P9/10; A61P25/00; A61P25/08; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P43/00; C07C59/11; C07C229/10; C07C229/14; C07C229/18; C07C229/22; C07C229/28; C07C233/08; C07C271/22

Chika Takagi (2 outside)

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