Title:
【発明の名称】GnRH類似体
Document Type and Number:
Japanese Patent JP2522628
Kind Code:
B2
Abstract:
Peptides which include unnatural amino acids and which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. The peptides are analogs of the decapeptide GnRH wherein there is at least one residue of an unnatural amino acid U<*> in the 3-, 5- and/or 6-positions. Such unnatural amino acids are useful in the synthesis of peptides and can be formed after synthesis of the peptide chain. The unnatural amino acid U<*> can have a cyanoguanidino group on the omega carbon atom of the side chain, but preferably has formula U<*> (I) where j is 1 or 2 and R11 is H or an acyl radical having 1 to 6 carbon atoms.
Inventors:
HOEGER CARL A (US)
RIVIER JEAN EDOUARD FREDERIC (US)
THEOBALD PAULA GUESS (US)
PORTER JOHN S (US)
RIVIER CATHERINE LAURE (US)
VALE WYLIE WALKER JR (US)
RIVIER JEAN EDOUARD FREDERIC (US)
THEOBALD PAULA GUESS (US)
PORTER JOHN S (US)
RIVIER CATHERINE LAURE (US)
VALE WYLIE WALKER JR (US)
Application Number:
JP50831792A
Publication Date:
August 07, 1996
Filing Date:
March 11, 1992
Export Citation:
Assignee:
SALK INST FOR BIOLOGICAL STUDI (US)
International Classes:
A61K31/195; A61K31/275; A61K38/04; A61K31/495; A61K31/505; A61P5/00; A61P13/02; A61P15/00; C07C233/54; C07C233/87; C07C261/04; C07C279/24; C07C279/28; C07C327/38; C07C327/48; C07C333/08; C07C335/16; C07D209/14; C07D213/57; C07D233/64; C07D239/42; C07D241/20; C07D249/14; C07K1/113; C07K7/23; C07K14/575; A61K38/00; (IPC1-7): C07K14/575
Domestic Patent References:
| JP63233963A | ||||
| JP5035158A | ||||
| JP63201199A | ||||
| JP63264498A | ||||
| JP6425794A |
Other References:
ＴｅｔｒａｈｅｄｒｏｎＬｅｔｔｅｒｓ，Ｖｏｌ．３０，Ｎｏ．１１，ＰＰ．１４０１〜１４０４，１９８９Ｊ．Ｍｅｄ．Ｃｈｅｍ．１９９１．３４，２３９５−２４０２
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)
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