Title:
【発明の名称】ヒドロキソコバラミンの製造方法
Document Type and Number:
Japanese Patent JP3085320
Kind Code:
B2
Abstract:
A process for the production of hydroxocobalamin comprising the steps of: (1) putting a solution containing Co-enzyme type vitamin B12 contact with a divinylbenzene/styrene copolymer resin so that the Co-enzyme type vitamin B12 is adsorbed in the resin; (2) washing the resin with purified water or aqueous washing solution at a temperature between 30 DEG C and 70 DEG C so as to remove purities; (3) extracting the Co-enzyme type vitamin B12 adsorbed on the resin with an aqueous solution containing at least 25% by of a lower alcohol, so as to obtain an elute containing Co-enzyme type vitamin B12; (4) irradiating the elute with a light so as to convert Co-enzyme type vitamin B12 to hydroxocobalamin; and (5) treating the hydroxocobalamin-containing solution from step (4) with an inorganic adsorbent and recovering the hydroxocobalamin.
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Inventors:
Takayuki Hirayama
Takashi Kiyota
Takashi Kiyota
Application Number:
JP23648691A
Publication Date:
September 04, 2000
Filing Date:
September 17, 1991
Export Citation:
Assignee:
Nisseki Mitsubishi Corporation
International Classes:
C07H23/00; C12P19/42; C12R1/01; (IPC1-7): C07H23/00
Domestic Patent References:
| JP5791739A | ||||
| JP5792000A | ||||
| JP5995298A | ||||
| JP462029B1 |
Attorney, Agent or Firm:
Aoki Akira (4 outside)