Title:
【発明の名称】好中球活性化因子
Document Type and Number:
Japanese Patent JP3133305
Kind Code:
B2
Abstract:
Neutrophil-activating factor (NAF) is claimed. More specifically it has the qiven complete amino acid sequence. Also claimed is DNA having the nucleotide sequence indicated and equivalents suitable for expression in E.coli of NAF. - The total amino acid sequence of NAF purified from LPS-stimulated human monocytes has been detd. and a gene coding for the main NAF species synthesised and expressed as a recombinant peptide with the same neutrophil-activating properties as its natural homologue.
Inventors:
Asiawell, Heinrich
Lindley, Ivan James Dalton
Peveri, Paola
Waltz, alfred
Lindley, Ivan James Dalton
Peveri, Paola
Waltz, alfred
Application Number:
JP50943488A
Publication Date:
February 05, 2001
Filing Date:
November 12, 1988
Export Citation:
Assignee:
Novartis Actien Gezel Shaft
Theodor Kocher Institute
Theodor Kocher Institute
International Classes:
A47L5/36; A47L9/00; A61K38/00; A61P11/00; A61P17/00; A61P29/00; A61P31/00; A61P31/04; A61P31/12; C07H21/04; C07K1/16; C12N1/21; C07K1/20; C07K1/22; C07K14/47; C07K14/52; C07K14/53; C07K14/54; C12N1/14; C12N1/20; C12N5/00; C12N15/00; C12N15/09; C12N15/12; C12N15/19; C12N15/70; C12P19/34; C12P21/02; C12R1/19; C12R1/91; (IPC1-7): C07K14/47; A61K38/00; A61P29/00; C07K1/16; C12N15/09; C12P21/02
Domestic Patent References:
| JP2502097A |
Other References:
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Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)