Title:
【発明の名称】新規ペプチド
Document Type and Number:
Japanese Patent JPH10502619
Kind Code:
A
Abstract:
Oligopeptides which comprise amino acid sequences that are recognized and proteolytically cleaved by free prostate specific antigen (PSA) are described. Also described are assays which comprise such oligopeptides useful for determining free PSA protease activity in vitro and in vivo. Therapeutic agents which comprise conjugates of such oligopeptides and known cytotoxic agents are also described.
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Inventors:
Def Age Jones, Deborah
Fuen, Don-May
Garsky, victor em
Raymond Y
Oliff, Allen Eye
Fuen, Don-May
Garsky, victor em
Raymond Y
Oliff, Allen Eye
Application Number:
JP50342295A
Publication Date:
March 10, 1998
Filing Date:
June 07, 1995
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/195; A61K38/00; A61K38/08; A61K47/48; A61P13/08; A61P35/00; A61P43/00; C07H15/24; G01N33/566; C07K7/06; C07K7/08; C07K14/47; C07K17/08; C12Q1/37; G01N33/574; (IPC1-7): C07K14/47; A61K38/00; C07K7/06; C07K7/08; C12Q1/37; G01N33/566; G01N33/574
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)