Title:
【発明の名称】新規ビタミンD類似体
Document Type and Number:
Japanese Patent JP2000511894
Kind Code:
A
Abstract:
The present invention relates to compounds of formula (I), in which formula X is hydrogen or hydroxy; R1 and R2, which may be the same or different, stand for hydrogen or a C1-C3 alkyl radical; or R1 and R2, taken together with the carbon atom bearing the group X, can form a C3-C6 carbocyclic ring, R3 stands for a C1-C3 alkyl radical, an aryl or an aralkyl radical, or for YR4, in which Y stands for the radicals -CO-S-, -CS-O- or -CS-S-, and R4 stands for a C1-C3 alkyl radical or an aryl or an aralkyl radical; Q is (CH2)n, n being 1-4. R1, R2 and Q independently may optionally be substituted with one or more fluorine atoms. The compounds show strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells as well as immunomodulating and antiinflammatory effects.
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Inventors:
Tateen, Claus-Guyunter
Application Number:
JP50010698A
Publication Date:
September 12, 2000
Filing Date:
May 15, 1997
Export Citation:
Assignee:
Leo Pharmaceutical Products Limited Actiesel Scab (Lebens Chemisque Fabric Production Actiesl Scab)
International Classes:
A61K31/00; A61K31/59; A61K31/593; A61P3/00; A61P3/10; A61P9/00; A61P9/12; A61P13/00; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P17/10; A61P17/14; A61P19/00; A61P19/02; A61P19/10; A61P25/00; A61P25/28; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61P43/00; C07C401/00; (IPC1-7): C07C401/00; A61P3/10; A61P9/12; A61P13/12; A61P17/06; A61P17/02; A61P17/10; A61P17/14; A61P19/10; A61P19/02; A61P25/00; A61P25/28; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P37/06; A61P43/00; A61K31/593
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)