Title:
【発明の名称】薬学的調合剤
Document Type and Number:
Japanese Patent JPH0643312
Kind Code:
B2
Abstract:
A controlled absorption diltiazem formulation for oral administration comprises a pellet having a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid and a lubricant, and an outer membrane which permits release of diltiazem in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured according to the Paddle Method of U.S. Pharmacopoeia XX, is not more than 10% of the total diltiazem after 2 hours of measurement in a buffered medium. Not more than 30% of the total diltiazem is released after a total of 4 hours measurement and not more than 40% of the total diltiazem is released after a total of 6 hours. 100% release is achieved after 12 hours, with a maximum of 80% of the total diltiazem being released after 8 hours.
Inventors:
DONARUDO YUUJIEN PANOOZU
Application Number:
JP27058484A
Publication Date:
June 08, 1994
Filing Date:
December 21, 1984
Export Citation:
Assignee:
ELAN CORP PLC
International Classes:
A61K9/00; A61K9/16; A61K9/22; C07D281/10; A61K9/48; A61K9/50; A61K9/52; A61K9/62; A61K31/55; A61K31/554; A61P3/00; A61P9/08; A61P9/10; (IPC1-7): A61K31/55; A61K9/16; A61K9/48
Domestic Patent References:
| JP5839618A | ||||
| JP56122311A |
Attorney, Agent or Firm:
Masahiko Takeda (2 outside)