Title:
【発明の名称】プロテアーゼ阻害物質
Document Type and Number:
Japanese Patent JP2002501502
Kind Code:
A
Abstract:
Compounds of formula (I), wherein R is an aromatic or a heteroaromatic ring; R<2> and R<3> are H, C1-C8alkyl, aryl, arylC1-C8alkyl, or heteroaryl; R<4> is an aromatic or a heteroaromatic ring or an amine; W, X, Y, are independently selected from the group consisting of CH, N, S, or O, provided that at least one of W, X, and Y is a heteroatom, which inhibit protease, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease therewith.
Inventors:
Death Jar Race, Rene Louise
Duffy, Kevin James
Halbert, Stacy Marie
Keenan, Richard McRoch
Michaud, Yvelines
Scott Kevin, Thompson
Bever, daniel frank
Duffy, Kevin James
Halbert, Stacy Marie
Keenan, Richard McRoch
Michaud, Yvelines
Scott Kevin, Thompson
Bever, daniel frank
Application Number:
JP54708198A
Publication Date:
January 15, 2002
Filing Date:
April 23, 1998
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
C07D277/20; A61K31/426; A61K31/427; A61K31/4439; A61K31/4709; A61P1/02; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P43/00; C07C43/285; C07C43/295; C07C65/24; C07C69/92; C07C205/26; C07C205/37; C07C217/90; C07C235/28; C07C243/22; C07C335/26; C07D215/18; C07D215/227; C07D215/38; C07D277/32; C07D277/56; C07D417/12; C07F5/02; C07D215/22; (IPC1-7): C07D277/56; A61K31/426; A61K31/427; A61K31/4439; A61K31/4709; A61P1/02; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P43/00; C07D417/12
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)