Title:
【発明の名称】置換されたピラゾロピリミジンの合成
Document Type and Number:
Japanese Patent JP2003506453
Kind Code:
A
Abstract:
Methods of making substituted pyrazolopyrimidines generally and, more particularly, N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl}phenyl)acetamide. Such compounds have utility over a wide range of indications, including treatment of insomnia. In the practice of the present invention, improved techniques which do not require use and/or isolation of the pyrazole intermediate are disclosed, as well as improved techniques for making the reaction intermediates themselves. Such techniques offer significant advantages, including enhanced efficiency, particularly in the context of large scale manufacture.
Inventors:
Gloss, Raymond S.
Wilcoxen, Keith M.
Wilcoxen, Keith M.
Application Number:
JP2001515677A
Publication Date:
February 18, 2003
Filing Date:
August 10, 2000
Export Citation:
Assignee:
Neurocline Biosciences, Inc.
International Classes:
C07B61/00; C07C231/08; C07C233/43; C07D487/04; (IPC1-7): C07D487/04; C07C231/08; C07C233/43
Domestic Patent References:
| JPS6019788A | 1985-01-31 | |||
| JPH0995460A | 1997-04-08 |
Attorney, Agent or Firm:
Shusaku Yamamoto