Title:
【発明の名称】α1aアドレナリン受容体拮抗薬
Document Type and Number:
Japanese Patent JP2002511085
Kind Code:
A
Abstract:
This invention relates to certain novel compounds and derivates thereof, their synthesis, and their use as alpha 1a adrenergic receptor antogonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.
Inventors:
Pattern, Michael A.
Bock, Mark Gee
Rundle Sea, Newton
Rug, balat
Bock, Mark Gee
Rundle Sea, Newton
Rug, balat
Application Number:
JP50471599A
Publication Date:
April 09, 2002
Filing Date:
June 17, 1998
Export Citation:
Assignee:
Merck End Company, Inc.
Synaptic Pharmaceutical Co., Ltd.
Synaptic Pharmaceutical Co., Ltd.
International Classes:
C07D487/04; A61K31/451; A61K31/454; A61K31/513; A61K31/519; A61P13/02; A61P13/08; A61P43/00; C07D211/58; C07D265/32; C07D401/12; C07D401/14; C07D403/12; C07D405/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D491/04; C07D491/048; C07D491/10; (IPC1-7): C07D211/58; A61K31/451; A61K31/454; A61K31/513; A61K31/519; A61P13/02; A61P13/08; A61P43/00; C07D401/12; C07D401/14; C07D403/12; C07D405/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D487/04; C07D491/048; C07D491/10
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)