【発明の名称】TACE阻害剤としてのアルキニル含有ヒドロキサム酸化合物

Japanese Patent JP2002535384

A

The invention concerns compounds of formula (I) which are useful in treating disease conditions mediated by TNF- alpha , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

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Levin, The Elemiy Iron
Bencatesan, Alana Pacum Mudounbai
Cole, Derek Cecil
Chien, the ames ming
Davis, Jamie Marie
Gloss, Gioji Theodore

JP2000595970A

October 22, 2002

January 27, 2000

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American Cyanamid Company

A61K31/16; A61K31/351; A61K31/352; A61K31/381; A61K31/382; A61K31/40; A61K31/4035; A61K31/4045; A61K31/4406; A61K31/445; A61K31/4453; A61K31/4465; A61K31/47; A61K31/472; A61P1/04; A61P9/04; A61P19/02; A61P29/00; A61P31/18; A61P37/00; A61P43/00; C07C259/06; C07C259/10; C07C315/04; C07C317/22; C07C317/44; C07C319/20; C07C323/20; C07C323/60; C07D207/34; C07D209/14; C07D209/18; C07D209/48; C07D211/34; C07D213/56; C07D213/82; C07D215/16; C07D215/48; C07D215/54; C07D217/06; C07D217/26; C07D295/08; C07D295/092; C07D309/04; C07D309/10; C07D311/84; C07D333/20; C07D333/24; C07D333/58; C07D333/60; C07D335/02; C07D335/04; (IPC1-7): C07C259/10; A61K31/16; A61K31/351; A61K31/352; A61K31/381; A61K31/382; A61K31/40; A61K31/4035; A61K31/4045; A61K31/4406; A61K31/445; A61K31/4453; A61K31/4465; A61K31/47; A61K31/472; A61P1/04; A61P9/04; A61P29/00; A61P31/18; A61P37/00; A61P43/00; C07C315/04; C07C317/22; C07C319/20; C07C323/20; C07D207/34; C07D209/14; C07D209/48; C07D211/34; C07D213/82; C07D215/16; C07D217/26; C07D295/08; C07D309/10; C07D311/84; C07D333/20; C07D333/24; C07D333/58; C07D335/02

Heiyoshi Odashima

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