Title:
【発明の名称】微生物感染処置用組成物
Document Type and Number:
Japanese Patent JPS6036409
Kind Code:
B2
Abstract:
1405246 Potentiated antibacterial medicines WELLCOME FOUNDATION LTD 4 Aug 1972 [5 Aug 1971 1 Aug 1972] 36774/71 and 35817/72 Heading A5B Antibacterial compositions comprise a competitor of p-aminobenzoic acid or an inhibitor of dihydrofolate reductase, or both, together with a potentiator which is itself a pteridine antagonist (as defined in the specification) and which inhibits the enzyme hydroxymethyldihydropteridine pyrophosphokinase and has a sufficiently low toxicity to a mammalion or arian host. Specified potentiatas are compounds of the formula: wherein R is -alkyl, optionally substituted by a hydroxy group, a halogen atom or by a phenoxy group itself optionally substituted by one or more alkoxy, amino, alkyl or hydroxy groups or halogen atoms and R1 and R2 are the same or different and is each alkyl or they form: together a C 4-6 spirocycloalkyl ring system. Specified competitor/inhibitor compounds are various sulphonamides, pyrimethamine, trimethoprim, diaveridine and various derivatives of 2, 4-diamino pyrimidine. The compositions may be put up into conventional forms for oral, parenteral and rectal administration.
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Inventors:
JEEMUSU JOZEFU BAAGUHOORU
SUTANREE ROBAATO MORISU BUTSUS
ROBAATO KAREN
MAIKURU JON UIRIAMU DANKUREE
ROBAATO FUEROON
SUTANREE ROBAATO MORISU BUTSUS
ROBAATO KAREN
MAIKURU JON UIRIAMU DANKUREE
ROBAATO FUEROON
Application Number:
JP7824072A
Publication Date:
August 20, 1985
Filing Date:
August 04, 1972
Export Citation:
Assignee:
WELLCOME FOUND
International Classes:
A23K20/195; A61K31/495; A61K31/505; A61K31/519; A61K31/525; A61K31/63; A61K31/635; C07D475/04; (IPC1-7): A61K31/495
Attorney, Agent or Firm:
Naruhisa Asamura
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